Calcium in Urine and Blood
Hypercalcaemia and hypercalciuria
Hypercalcaemia (too much calcium in the blood) and hypercalciuria (too much calcium in the urine) can occur in a small but significant number of people with sarcoidosis. The disturbed calcium metabolism is probably related to increased activity of the body's own enzyme 1-alpha-hydroxylase, which in sarcoidosis is responsible for producing calcitriol, the active form of vitamin D.
Hypercalcaemia
Hypercalcaemia is found in 5–10% of people with sarcoidosis. It results from increased activity of 1-alpha-hydroxylase, which in sarcoidosis converts various forms of vitamin D—from sunlight, food or supplements—into its activ
Calcium in Urine and Blood
Hypercalcaemia and hypercalciuria
Hypercalcaemia (too much calcium in the blood) and hypercalciuria (too much calcium in the urine) can occur in a small but significant number of people with sarcoidosis. The disturbed calcium metabolism is probably related to increased activity of the body's own enzyme 1-alpha-hydroxylase, which in sarcoidosis is responsible for producing calcitriol, the active form of vitamin D<p>Calcium in Urine and Blood</p><p>Hypercalcaemia and hypercalciuria<br>Hypercalcaemia (too much calcium in the blood) and hypercalciuria (too much calcium in the urine) can occur in a small but significant number of people with sarcoidosis. The disturbed calcium metabolism is probably related to increased activity of the body's own enzyme 1-alpha-hydroxylase, which in sarcoidosis is responsible for producing calcitriol, the active form of vitamin D.</p><p>Hypercalcaemia<br>Hypercalcaemia is found in 5–10% of people with sarcoidosis. It results from increased activity of 1-alpha-hydroxylase, which in sarcoidosis converts various forms of vitamin D—from sunlight, food or supplements—into its active form.</p><p>Hypercalcaemia impairs the body's ability to carry out normal functions and can be life-threatening in some cases. It is associated with impaired kidney function and, in up to half of people with hypercalcaemia, even kidney failure.</p><p>If regular blood tests—whether performed while investigating symptoms or by chance—show that a person with sarcoidosis has hypercalcaemia, vitamin D levels, parathyroid hormone (PTH), 24-hour urinary calcium excretion and kidney function (urine, creatinine and electrolytes) should be checked. Primary hyperparathyroidism must be excluded.</p><p>Sun exposure and vitamin D supplements can often cause hypercalcaemia. Severity depends on many factors; however, hypercalcaemia in sarcoidosis usually responds well to treatment.</p>.
Hypercalcaemia
Hypercalcaemia is found in 5–10% of people with sarcoidosis. It results from increased activity of 1-alpha-hydroxylase, which in sarcoidosis converts various forms of vitamin D—from sunlight, food or supplements—into its active form.
e form.
Hypercalcaemia impairs the body's ability to carry out normal functions and can be life-threatening in some cases. It is associated with impaired kidney function and, in up to half of people with hypercalcaemia, even kidney failure.
If regular blood tests—whether performed while investigating symptoms or by chance—show that a person with sarcoidosis has hypercalcaemia, vitamin D levels, parathyroid hormone (PTH), 24-hour urinary calcium excretion and kidney function (urine, creatinine and electrolytes) should be checked. Primary hyperparathyroidism must be excluded.
Sun exposure and vitamin D supplements can often cause hypercalcaemia. Severity depends on many factors; however, hypercalcaemia in sarcoidosis usually responds well to treatment.
Hypercalciuria
Hypercalciuria is much more common than hypercalcaemia: between 30 and 40% of people with sarcoidosis have elevated calcium levels in the urine.
<p>Hypercalciuria</p><p>Hypercalciuria is much more common than hypercalcaemia: between 30 and 40% of people with sarcoidosis have elevated calcium levels in the urine.</p><p>Excess calcium in the urine can cause problems because it tends to form salts that crystallise. Depending on their size and location, these crystals can cause pain or other urinary symptoms. Larger crystals are called kidney stones.</p>Excess calcium in the urine can cause problems because it tends to form salts that crystallise. Depending on their size and location, these crystals can cause pain or other urinary symptoms. Larger crystals are called kidney stones.
Treatment of hypercalcaemia and hypercalciuria
Sarcoidosis-related hypercalcaemia is well described in connection with specific sarcoidosis treatments. Steroids are used first, together with non-specific measures such as adequate fluid intake (for example intravenous fluids) and sometimes diuretics.<p>Treatment of hypercalcaemia and hypercalciuria</p><p>Sarcoidosis-related hypercalcaemia is well described in connection with specific sarcoidosis treatments. Steroids are used first, together with non-specific measures such as adequate fluid intake (for example intravenous fluids) and sometimes diuretics.</p><p>Depending on the blood calcium level, hospital admission for intravenous fluids may be needed. Consistent monitoring of calcium levels is essential to ensure that the condition does not worsen and to reduce the risk of additional medication side effects.</p>
Depending on the blood calcium level, hospital admission for intravenous fluids may be needed. Consistent monitoring of calcium levels is essential to ensure that the condition does not worsen and to reduce the risk of additional medication side effects.
Bei einer leichten Hyperkalziurie kann die Erkrankung durch eine Ernährungsumstellung und das Absetzen von Vitamin-D-Präparaten kontrolliert werden. Auch eine Begrenzung der Zeit in der Sonne kann erwogen werden.
Wenn diese Maßnahmen nicht erfolgreich sind, kann eine Hyperkalziurie auf eine aktive systemische Sarkoidose hinweisen. In diesem Fall kann eine Behandlung mit Steroiden und anderen Medikamenten erwogen werden.
Quelle: https://www.sarcoidosisuk.org/hypercalcaemia-and-hypercalciuria/